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Research has found that these oxalate crystals cause inflammation, scarring and even renal failure in those with kidney disease.[1] Reports of Kidney Failure with Vitamin C A 2015 study reported a case of sudden kidney failure due to oxalate nephropathy in a woman who ingested a high amount of vitamin C.[2] A 2022 study reported kidney failure after high ingestion of vitamin C, and when the kidneys were biopsied they found extensive crystals throughout the tissues of the kidney.[3] A 2023 study again reported a patient with high-dose vitamin C-induced acute oxalate nephropathy (kidney disease).[4] Is Some Vitamin C Good