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Besides Smad pathways, studies have shown that TGF-β signaling through other non-canonical pathways, including mitogen activated protein kinase (MAPK) pathways, phosphatidylinositol-3-kinase (PI3K) pathway, and Rho-like GTPase pathways, are also critical for eliciting TGF-β's profibrogenic activity [25], [38], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61]
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