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336,337 Expression of antioxidants either fails to be induced or is decreased, allowing increased expression of reactive oxygen species to affect tubulointerstitial fibrosis through necrosis, apoptosis, activation of interstitial fibroblasts and pericytes, proliferation of endothelial cells, and epithelial-mesenchyme transition (figure 1)

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Its tyrosine phosphorylation markedly reduces the affinity of band 3 to ankyrin, causing destabilization of the band 3-cytoskeleton interaction, increases the lateral mobility of band 3 within the membrane and induces vesiculation (Ferru et al., 2011)