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Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases - PMC
To understand the strong association between DS and AD neuropathology, first it is necessary to consider the trisomy of Chr21, in which the overexpression of selected genes already has been identified to be involved in the development of AD neuropathology in the general population (457) (FIGURE 11)
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