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Interestingly, selective inhibition of COX-2, responsible for PGE2 biosynthesis, reduced the levels of pro-inflammatory cytokines in DES apparently via the attenuating effect of PGE2 on antigen-presenting dendritic cells [24], indicating the existence of interrelation between inflammatory pathways in DES
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The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases
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