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The binding of the second TOPBP1 AAD also creates an intermediate tβ1α3–ATR interface by inducing FAT movement at the closed protomer (Extended Data Fig
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NAD⁺ Elevation in Cell Models Cell-based studies have confirmed that 5-Amino-1MQ treatment raises intracellular NAD⁺ levels in adipocytes and other cell types , consistent with the proposed mechanism of redirecting nicotinamide from NNMT-mediated methylation towards NAD⁺ biosynthesis
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