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Despite the breadth of preclinical literature, human clinical evidence is limited and largely confined to small uncontrolled studies from the 1980s and 1990s, with mixed and difficult-to-interpret results

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Background Senescence occurs after the development and maturation of cells (1), which means matured cells stop dividing, while they are metabolically active, mainly due to lack of DNA replication (1, 2) and unusual changes in the gene expression (3)